TRANs-BEE - Synthesising transcriptome data to explore interspecies bee-pathogen molecular interactions that may underpin pollinator decline

First meeting: 10.-11.10.2013

PIs:
Christina Grozinger
Robert Paxton

Working group postdoc:
Vincent Doublet

iDiv member:
Robert Paxton

Project summary:
The primary objective of the workshops is to bring together data generators and data analysts to synthesise results on the impact of pathogenic organisms on the honey bee transcriptome, with the aim of providing a functional analysis of this host’s response to microbial challenge. The workshops will provide the forum for the necessary integration of microarray and nextgen sequence data into a single, comprehensive dataset, statistical evaluation of up/down regulation of transcripts/metabolic pathways, and comparison with Drosophila functional analysis of transcriptome response to pathogen challenge. The outcome will be a research article reviewing the field, synthesising datasets (meta-analysis) and providing recommendations for technical developments as well as a pipeline to facilitate future research on the analysis and interpretation of honey bee (and other insect) transcriptome data.

Group members:
Cédric Alaux (INRA-Avignon), Cristian Aurori (University of Agricultural Sciences and Veterinary Medicine), Seth Michael Barribeau (ETH Zurich), James C. Bull (Swansea University), Vincent Doublet (Martin Luther University Halle-Wittenberg), Michelle Flenniken (Monatana State University - College of Agriculture), Andreas Gogol-Doering (German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig), Ivo Große (Martin Luther University Halle-Wittenberg), Christina M. Grozinger (Penn State University), Qiang Huang (Martin Luther University Halle-Wittenberg), Dan Hultmark (Umeå University), Christoph Kurze (Martin Luther University Halle-Wittenberg), H. Michael G. Lattorff (Martin Luther University Halle-Wittenberg), Yves Le Conte (INRA - Laboratoire de Biologie et Protection de l'abeille), Fabio Manfredini (University of London), Dino P. McMahon (Martin Luther University Halle-Wittenberg), Robin F.A. Moritz, Myrsini E. Natsopoulou (Martin Luther University Halle-Wittenberg), Francesco Nazzi (Universitá de Udine), Elina Lastro Niño (Penn State University), Katja Nowick (Leipzig University), Robert J. Paxton (Martin Luther University Halle-Wittenberg), Oscar Bedoya Reina (Penn State University), Eckart Stolle (Martin Luther University Halle-Wittenberg)

Meeting report


Second meeting: 28.-29.4.2014

Group members:
Seth Michael Barribeau (ETH Zurich), Mark Brown (Royal Holloway University of London), James C. Bull (Swansea University), Vincent Doublet (Martin-Luther-University Halle-Wittenberg), Michelle Flenniken (Monatana State University - College of Agriculture), Elke Genersch (Institute for Bee Research), Andreas Gogol-Doering (German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig), Christina M. Grozinger (Penn State University), H. Michael G. Lattorff (Martin-Luther-University Halle-Wittenberg), Elina Lastro Niño (Penn State University), Katja Nowick (University of Leipzig), Dino P. McMahon (Martin-Luther-University Halle-Wittenberg), Francesco Nazzi (Universitá de Udine), Katja Nowik (University of Leipzig), Robert J. Paxton (Martin-Luther-University Halle-Wittenberg), Yvonne Poeschl (German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig), Ronald von Rij (Radboud University Nijmegen Medical Centre)

Meeting report

 

Publications:

Poeschl, Y., Grosse, I. & Gogol-Döring, A. (2014) Explaining gene responses by linear modeling. In: German conference on bioinformatics, pp. 27-35. see here

Vincent Doublet, Yvonne Poeschl, et al. (2017). Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens. BMC Genomics 18:207. see here

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